Author

D. Osti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:zebrafish· 1

Frequent Co-Authors

G. Pelicci· 2 shared S. Faletti· 2 shared A. Cavalli· 1 shared A. Fantin· 1 shared A. Izzo· 1 shared A. P. Masilamani· 1 shared A. Wasilenko· 1 shared B. Balboni· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

G. Pelicci

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2 papers

Recent·Most cited

Metformin antiproliferative activity is exclusively mediated by the membrane functional expression of the Chloride Intracellular Channel 1 in glioblastoma stem cells

I. Verduci, F. Cianci, R. Cazzoli, G. Cannavale, M. Veronesi, B. Balboni, M. Ranucci, L. M. G. Palloni, C. Richichi, S. Faletti, D. Osti, G. Ailuno, G. Caviglioli, C. Tacconi, S. GIROTTO, , M. Mazzanti

This study identifies tmCLIC1 as the specific metformin receptor in glioblastoma stem cells, showing that metformin's antiproliferative effect depends on its binding to tmCLIC1 and subsequent inhibition of mitochondrial respiration.

bioRxiv · Dec 31, 2022 · PreprintCancer Biology

ZBTB18 inhibits SREBP-dependent fatty acid synthesis by counteracting CTBPs and KDM1A/LSD1 activity in glioblastoma

R. Ferrarese, A. Izzo, G. Andrieux, S. Lagies, J. P. Bartmuss, A. P. Masilamani, A. Wasilenko, D. Osti, S. Faletti, R. Schulzki, S. Yuan, E. Kling, V. Ribecco, H. D. Heiland, S. G. Tholen, , M. S. Carro

This study identifies ZBTB18 as a regulator of SREBP gene expression in glioblastoma by modulating CTBP and LSD1 activity, leading to epigenetic repression of fatty acid synthesis.

bioRxiv · Apr 17, 2020 · PreprintCancer Biology