D. P. O'Brien

This study identifies USP16 as an ISG15 cross-reactive deubiquitinase that regulates metabolic pathway-related proteins during type I interferon responses.

The paper identifies 46 novel proteins interacting with CLR in primary human dermal lymphatic endothelial cells using immunoprecipitation and mass spectrometry, confirmed by proximity ligation assay.

This study investigates how a benzosulfonamide compound inhibits USP30, a mitochondrial deubiquitylating enzyme, using biochemical and structural methods to reveal its binding mechanism and selectivity.

This study identifies a ten-protein diagnostic signature for Japanese encephalitis virus infection in cerebrospinal fluid with >99% accuracy using proteomics and machine learning.

This study uses integrative omics to detect subtle molecular changes in porcine kidneys after remote ischemic conditioning, finding reduced inflammation and potential fibrosis markers.