Pharmacology & ToxicologybioRxiv
High impact AMPAkines induce a Gq-protein coupled endoplasmic calcium release in cortical neurons: a possible mechanism for explaining the toxicity of high impact AMPAkines
D. P. Radin, S. Zhong, R. Cerne…·A. Lippa
This study shows high impact AMPAkines induce Gq-protein mediated calcium release from ER stores in neurons, explaining their toxicity compared to low impact AMPAkines.
DOI 10.1002/syn.22310