APP substrate ectodomain defines A beta length by restraining gamma-secretase processivity and facilitating product release
M. Koch, T. Enzlein, S.-Y. Chen, D. Petit, S. Lismont, M. Zacharias, C. Hopf, L. Chavez-Gutierrez
The paper investigates how the APP ectodomain regulates gamma-secretase processivity and A beta peptide length, identifying it as a target for Alzheimer's disease therapies.
bioRxiv · Sep 13, 2023 · PreprintBiochemistry