BiochemistrybioRxivPreprint
APP substrate ectodomain defines A beta length by restraining gamma-secretase processivity and facilitating product release
M. Koch, T. Enzlein, S.-Y. Chen…·L. Chavez-Gutierrez
The paper investigates how the APP ectodomain regulates gamma-secretase processivity and A beta peptide length, identifying it as a target for Alzheimer's disease therapies.
DOI 10.1101/2023.09.13.557360