Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control
B. Mahata, A. Cabrera, D. A. Brenner, R. S. Guerra-Resendez, J. Li, J. Goell, K. Wang, Y. Guo, M. Escobar, A. K. Parthasarathy, H. Szadowski, G. Bedford, D. Reed, I. B. Hilton
This paper develops compact human mechanosensitive TADs for synthetic transcriptional control, showing they are potent, versatile, and well-tolerated in primary cells.
bioRxiv · Mar 21, 2022Bioengineering