BiochemistrybioRxiv
Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response
J. Krakowiak, X. Zheng, N. Patel…·D. Pincus
The paper validates a mathematical model of the yeast heat shock response by showing Hsp70-mediated negative feedback regulates Hsf1 activity through specific binding sites and domains.
DOI 10.7554/elife.31668