D. Sabatini

Dihydroxyacetone phosphate signals glucose availability to mTORC1

This study identifies dihydroxyacetone phosphate (DHAP) as the glucose-derived metabolite that activates mTORC1, linking glucose availability to cell growth regulation.

Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling

This study identifies RSH-1 as a lysosomal NADPH phosphatase that regulates ER proteostasis via mTOR signaling in C. elegans.