Structural basis of ion - substrate coupling in the Na+-dependent dicarboxylate transporter VcINDY
D. Sauer, J. J. Marden, J. C. Sudar, J. Song, C. Mulligan, D.-N. Wang
This study reveals the structural mechanism by which VcINDY couples sodium and substrate binding through an induced-fit mechanism, showing that sodium binding stabilizes the substrate binding site.
bioRxiv · Jan 11, 2022Biophysics