Author

E. Oswald

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:E. coli· 5 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J.-P. Nougayrede· 5 shared C. Massip· 3 shared C. V. Chagneau· 3 shared N. Bossuet-Greif· 3 shared P. Branchu· 3 shared C. Chagneau· 2 shared F. Taieb· 2 shared J.-P. Motta· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersMicrobiology

J.-P. Nougayrede

Mutual co-authors in cluster

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8 papers

Recent·Most cited

HlyF, an underestimated virulence factor of uropathogenic Escherichia coli

C. V. Chagneau, D. Payros, A. Goman, C. Goursat, L. David, M. Okuno, P.-J. Bordignon, C. Seguy, C. Massip, P. Branchu, Y. Ogura, J.-P. Nougayrede, M. Marenda, E. Oswald

The paper identifies HlyF as a virulence factor in UPEC strains associated with severe UTIs and urosepsis, showing its link to plasmid-mediated virulence and antimicrobial resistance.

bioRxiv · Apr 27, 2023 · PreprintMicrobiology

Oxygen concentration modulates colibactin production

N. Bossuet, C. Guyonnet, C. Chagneau, M. Tang-Fichaux, M. Penary, D. Loubet, P. Branchu, E. Oswald, J.-P. Nougayrede

This study shows that colibactin production in E. coli is maximal under anoxic conditions and decreases with oxygen concentration, suggesting adaptation to the intestinal environment.

bioRxiv · Jun 20, 2022Microbiology

The therapeutic potential of D-Serine in reducing expression of the cytopathic genotoxin colibactin

J. C. Hallam, N. O'Boyle, N. C. A. Turner, M. Tang-Fichaux, E. Oswald, A. J. Roe

This study shows D-Serine reduces colibactin expression and cytopathic effects in E. coli strains, suggesting its therapeutic potential for preventing colibactin-related diseases.

bioRxiv · Mar 8, 2022 · PreprintMicrobiology

Outer membrane vesicles produced by pathogenic strains of Escherichia coli block autophagic flux and exacerbate inflammasome activation

L. DAVID, F. Taieb, M. Penary, P.-J. Bordignon, R. Planes, S. Bagayoko, V. Duplan-Eche, E. Meunier, E. Oswald

The paper shows that OMVs from pathogenic E. coli block autophagic flux and enhance inflammasome activation, contributing to disease severity.

bioRxiv · Apr 20, 2021Microbiology

Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population

F. Auvray, A. Perrat, Y. Arimizu, C. V. Chagneau, N. Bossuet-Greif, C. Massip, H. Brugere, J.-P. Nougayrede, T. Hayashi, P. Branchu, Y. Ogura, E. Oswald

This study identifies the distribution and functionality of the pks island in E. coli strains, showing its presence across multiple phylogroups and its role in colibactin production.

bioRxiv · Apr 13, 2021Microbiology

A toxic friend: Genotoxic and mutagenic activity of the probiotic strain Escherichia coli Nissle 1917

J.-P. Nougayrede, C. Chagneau, J.-P. Motta, N. Bossuet-Greif, M. Belloy, F. Taieb, J.-J. Gratadoux, M. Thomas, P. Langella, E. Oswald

This study shows that the probiotic Escherichia coli Nissle 1917 produces the genotoxin colibactin, which induces DNA damage and mutagenesis in vitro and in vivo.

bioRxiv · Mar 22, 2021Microbiology

Diversity and prevalence of colibactin- and yersiniabactin encoding mobile genetic elements in enterobacterial populations: insights into evolution and co-existence of two bacterial secondary metabolite determinants

H. Wami, A. Wallenstein, D. Sauer, M. Stoll, R. von Buenau, E. Oswald, R. Mueller, U. Dobrindt

The paper investigates the diversity and prevalence of colibactin and yersiniabactin encoding elements in enterobacteria, finding species-specific lineages and horizontal gene transfer mechanisms.

bioRxiv · Jan 22, 2021Microbiology

Uropathogenic E. coli induces DNA damage in the bladder

C. V. Chagneau, C. Massip, N. Bossuet-Greif, C. Fremez, J.-P. Motta, A. Shima, C. Besson, P. Le Faouder, N. Cenac, M.-P. Roth, H. Coppin, M. Fontanie, P. Martin, J.-P. Nougayrede, E. Oswald

The paper reports colibactin production in human UTIs and its genotoxic effects on bladder cells, linking it to potential bladder cancer risk.

bioRxiv · May 7, 2020 · PreprintMicrobiology