D. Schaack

Acod1 negatively impacts osteoclastogenesis via GPR91-mediated NFATc1 activation

This paper shows that Acod1 overexpression suppresses osteoclastogenesis by increasing succinate levels, which activates NFATc1 via GPR91, but this activation does not fully drive osteoclast differentiation.

Gαq modulates the energy metabolism of osteoclasts

This study shows that Gαq enhances osteoclast energy metabolism by promoting glycolysis and mitochondrial respiration, contributing to increased bone resorption.