A. Hafner

Norovirus NS1/2 protein increases glutaminolysis for efficient viral replication

This study identifies that the Norovirus NS1/2 protein enhances glutaminolysis to support viral replication in macrophages.

Loop stacking organizes genome folding from TADs to chromosomes

This study uses super-resolution microscopy to show that CTCF and cohesin organize chromatin loops at the single-cell level, influencing genome folding and gene expression variability.

Gαq modulates the energy metabolism of osteoclasts

This study shows that Gαq enhances osteoclast energy metabolism by promoting glycolysis and mitochondrial respiration, contributing to increased bone resorption.

How subtle changes in 3D structure can create large changes in transcription

The paper proposes a futile cycle model to explain how small changes in 3D genomic structure can lead to large transcriptional changes, challenging existing models.

Proteasome-mediated protein degradation resets the cell division cycle and triggers ESCRT-III-mediated cytokinesis in an archaeon

This study identifies proteasome-mediated degradation of CdvB as a mechanism resetting the cell division cycle and triggering cytokinesis in the archaeon Sulfolobus acidocaldarius.