Author

W. Wagner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Cancer Biology· 2 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Research Focus:cell type annotation· 7 Approach:experimental assay· 7 Research Focus:differential expression· 5 Assay:DNA methylation· 5 Research Focus:chromatin & epigenetic regulation· 4 Assay:bulk RNA-seq· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

M. Zenke· 4 shared R. Goetzke· 4 shared K. Zeevaert· 3 shared M. H. Elsafi Mabrouk· 3 shared A.-C. Henneke· 2 shared C. Maassen· 2 shared I. G. Costa· 2 shared J. Franzen· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersCell Biology

M. Zenke

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Cancer-associated fibroblasts reveal aberrant DNA methylation across different types of cancer

M. Schmidt, T. Maie, I. G. Costa, W. Wagner

The paper identifies aberrant DNA methylation in cancer-associated fibroblasts across multiple cancer types and links these changes to patient prognosis.

bioRxiv · Feb 2, 2024Cancer Biology

Substrate elasticity does not impact on DNA methylation changes during differentiation of pluripotent stem cells

M. H. Elsafi Mabrouk, K. Zeevaert, A.-C. Henneke, C. Maassen, W. Wagner

This study shows that substrate elasticity does not affect DNA methylation changes during iPSC differentiation, but epigenetic differences are observed between PDMS and TCP substrates.

bioRxiv · Jan 16, 2024Cell Biology

Longitudinal Micro-Computed Tomography Detects Onset and Progression of Pulmonary Fibrosis in Conditional Nedd4-2 Deficient Mice

D. H. W. Leitz, P. Konietzke, W. Wagner, M. Mertiny, C. Benke, T. Schneider, W. Stiller, H.-U. Kauczor, M. A. Mall, J. Duerr, M. O. Wielpuetz

This study uses longitudinal micro-CT to detect and quantify the onset and progression of IPF-like lung disease in Nedd4-2-/- mice.

bioRxiv · Aug 31, 2023 · PreprintPathology

YAP1 is essential for self-organized differentiation of pluripotent stem cells

K. Zeevaert, R. Goetzke, M. H. Elsafi Mabrouk, M. Schmidt, C. Maassen, A.-C. Henneke, C. He, A. Gillner, M. Zenke, W. Wagner

This study shows YAP1 is critical for germ layer specification in iPSCs, particularly in self-organized embryoid bodies, through NODAL pathway activation.

bioRxiv · Sep 29, 2022Cell Biology

Acod1 negatively impacts osteoclastogenesis via GPR91-mediated NFATc1 activation

Y. Gao, F. V. Kraus, E. Seebach, S. Chakraborty, D. Schaack, J. Schenz, W. Wagner, K. Kubatzky

This paper shows that Acod1 overexpression suppresses osteoclastogenesis by increasing succinate levels, which activates NFATc1 via GPR91, but this activation does not fully drive osteoclast differentiation.

bioRxiv · Apr 7, 2022 · PreprintImmunology

The spatial self-organization within pluripotent stem cell colonies is continued in detaching aggregates

M. H. Elsafi Mabrouk, R. Goetzke, G. Abagnale, B. Yesilyurt, L. Salz, K. Zeevaert, Z. Ma, M. A. S. Toledo, R. Li, I. G. Costa, V. Pachauri, U. Schnakenberg, M. Zenke, W. Wagner

The paper shows that self-organization in iPSC colonies continues in 3D aggregates formed after detachment from substrates, with maintained gene expression patterns.

Biomaterials · Mar 1, 2022Peer-reviewedCell Biology

DNMT3A knockouts in human iPSCs prevent de novo DNA methylation and reveal growth advantage during hematopoietic differentiation

O. Cypris, J. Franzen, J. Frobel, P. Glueck, C.-C. Kuo, S. Schmitz, S. Nuechtern, M. Zenke, W. Wagner

bioRxiv · Dec 15, 2021Cell Biology

Nintedanib Targets KIT D816V Neoplastic Cells Derived from Induced Pluripotent Stem cells of Systemic Mastocytosis

M. A. Szymanski de Toledo, M. Gatz, S. Sontag, K. V. Gleixer, G. Eisenwort, K. Feldberg, F. Kluge, R. Guareschi, G. Rossetti, A. S. Sechi, O. Dufva, S. M. Mustjoki, A. Maurer, H. M. Schueler, R. Goetzke, , M. Zenke

This study identifies nintedanib as a novel KIT D816V inhibitor effective against patient-derived neoplastic mast cells in systemic mastocytosis.

bioRxiv · May 6, 2020Cancer Biology

Senescence-associated metabolomic phenotype in primary and iPSC-derived mesenchymal stromal cells

E. Fernandez-Rebollo, J. Franzen, J. Hollmann, A. Ostrowska, M. Oliverio, T. Sieben, B. Rath, J.-W. Kornfeld, W. Wagner

This study compares the metabolomic changes in primary and iPSC-derived mesenchymal stromal cells during replicative senescence, finding similar metabolic shifts in both cell types.

bioRxiv · Feb 6, 2019Cell Biology

Interrupted reprogramming into induced pluripotent stem cells does not rejuvenate human mesenchymal stromal cells

C. Goebel, R. Goetzke, T. Eggermann, W. Wagner

This study shows that interrupting reprogramming of mesenchymal stromal cells into iPSCs does not rejuvenate the cells and may lead to chromosomal abnormalities.

bioRxiv · Jun 12, 2018Cell Biology