S. Keegan

D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens

This study uses CRISPR/Cas9 screens to identify SOCS1 as a target for enhancing T cell therapy, leading to the development of an engineered TIL therapy with improved anti-tumor function.

GEMspa: a Napari plugin for analysis of single particle tracking data

GEMspa is a Napari plugin that simplifies single particle tracking analysis for microrheology, providing a user-friendly interface and tools for extracting particle motion parameters.

KaryoCreate: a new CRISPR-based technology to generate chromosome-specific aneuploidy by targeting human centromeres

KaryoCreate generates chromosome-specific aneuploidy by targeting centromeres with CRISPR, showing it can induce gains or losses of targeted chromosomes in human cells.

nucGEMs probe the biophysical properties of the nucleoplasm

The paper introduces nucGEMs, fluorescent nanoparticles that probe nucleoplasm biophysical properties, revealing differences in motility, exclusion from heterochromatin, and effects of mitotic condensation.

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2

This paper presents a large repertoire of high-affinity nanobodies against SARS-CoV-2 Spike protein with potent neutralization properties and resistance to viral variants.

The ULK1-FBXW5-SEC23B nexus controls autophagy

This study identifies the ULK1-FBXW5-SEC23B pathway as a regulator of autophagy by controlling COPII localization and SEC23B stability during nutrient starvation.