Author

D. Spitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

A. J. Spracklen· 1 shared B. J. Sishc· 1 shared C. Heer· 1 shared C. Liu· 1 shared D. S. Ranasinghe· 1 shared D. Saha· 1 shared G. Walz· 1 shared H. H. Tam· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

A. J. Spracklen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ComboPath: An ML system for predicting drug combination effects with superior model specification

D. S. Ranasinghe, N. E. Sanders, H. H. Tam, C. Liu, D. Spitz

ComboPath predicts interpretable dose response surfaces for drug combinations using biophysically-motivated modeling, improving model specification and accuracy on combinatoric screening data.

bioRxiv · Jan 16, 2024 · PreprintBiophysics

Selective endocytosis controls slit diaphragm maintenance and dynamics.

K. Lang, J. Milosavljevic, H. Heinkele, M. Chen, L. Gerstner, D. Spitz, S. Kayser, M. Helmstaedter, G. Walz, M. Koettgen, A. J. Spracklen, J. S. Poulton, T. Hermle

This study investigates how selective endocytosis regulates slit diaphragm dynamics in Drosophila nephrocytes, revealing roles for dynamin and flotillin in maintaining filtration barrier function.

bioRxiv · Mar 1, 2022 · PreprintCell Biology

The superoxide dismutase mimetic GC4419 enhances tumor killing when combined with stereotactic ablative radiation

B. J. Sishc, L. Ding, C. Heer, D. Saha, D. Spitz, M. D. Story

GC4419 enhances tumor killing when combined with stereotactic ablative radiation in NSCLC and other cancers by generating hydrogen peroxide and altering inflammatory signaling.

bioRxiv · Mar 10, 2020 · PreprintCancer Biology