Author

D. Swami

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Miskalis· 2 shared G. Elias· 2 shared J. Winter· 2 shared M. Gapinske· 2 shared M. Stilger· 2 shared N. Gosstola· 2 shared P. Perez-Pinera· 2 shared S. Shirguppe· 2 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

A. Miskalis

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Author profile →

2 papers

Recent·Most cited

In vivo CRISPR base editing for treatment of Huntington's disease

S. Shirguppe, M. Gapinske, D. Swami, N. Gosstola, P. Acharya, A. Miskalis, D. Joulani, M. G. Szkwarek, A. Bhattacharjee, G. Elias, M. Stilger, J. Winter, W. S. Woods, D. Anand, C. K. W. Lim, , P. Perez-Pinera

This study uses CRISPR base editing to create HTT protein isoforms resistant to caspase-6 cleavage, reducing toxicity and neurodegeneration in a rodent HD model.

bioRxiv · Jul 5, 2024Bioengineering

SPLICER: A Highly Efficient Base Editing Toolbox That Enables In Vivo Therapeutic Exon Skipping

A. Miskalis, S. Shirguppe, J. Winter, G. Elias, D. Swami, A. Nambiar, M. Stilger, W. Woods, N. Gosstola, M. Gapinske, A. Zeballos, H. Moore, S. Maslov, T. Gaj, P. Perez-Pinera

SPLICER improves exon skipping by editing both splice acceptor and donor sites, reducing aberrant splicing and enabling therapeutic applications in Alzheimer's disease.

bioRxiv · Apr 1, 2024 · PreprintBioengineering