J. Winter

Spatiotemporal Modeling of Mitochondrial Network Architecture

This study models mitochondrial network dynamics using simulations and analytic models to show how local parameters control network morphology and remodeling rates.

In vivo CRISPR base editing for treatment of Huntington's disease

This study uses CRISPR base editing to create HTT protein isoforms resistant to caspase-6 cleavage, reducing toxicity and neurodegeneration in a rodent HD model.

SPLICER: A Highly Efficient Base Editing Toolbox That Enables In Vivo Therapeutic Exon Skipping

SPLICER improves exon skipping by editing both splice acceptor and donor sites, reducing aberrant splicing and enabling therapeutic applications in Alzheimer's disease.

Liver Endothelium Microenvironment Promotes HER3-mediated Cell Growth in Pancreatic ductal adenocarcinoma

This study shows liver endothelial cells promote PDAC growth via HER3-AKT signaling, suggesting HER3-targeted therapies for HER3-positive metastatic PDAC.

Genomic diversity of Helicobacter pylori populations from different regions of the human stomach.

This study uses whole-genome sequencing to analyze H. pylori genetic diversity within and between stomach regions, revealing extensive allelic diversity and recombination patterns.

Genome scale CRISPR Cas9a knockout screen reveals genes that controls glioblastoma susceptibility to the alkylating agent temozolomide

This study uses a genome-wide CRISPR-Cas9a knockout screen to identify genes influencing glioblastoma resistance to temozolomide.

NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to Temozolomide (TMZ) via NELFB and RPS6KB2 interaction.

This study identifies NSUN6 as an RNA methyltransferase that regulates glioblastoma response to temozolomide through 5mC-mediated control of NELFB and RPS6KB2.

Distinct molecular signatures of fission predict mitochondrial degradation or proliferation

The paper identifies two distinct fission types in mitochondria, one leading to degradation and the other to proliferation, both Drp1-mediated but using different adaptors and pre-constriction mechanisms.

Liver Endothelium Promotes HER3-mediated Cell Survival in KRAS Wild-type and Mutant Colorectal Cancer Cells

The paper shows liver endothelial cells promote HER3-mediated survival in KRAS wild-type and mutant colorectal cancer cells through secreted factors, suggesting HER3 as a therapeutic target regardless of KRAS mutation status.

Isolation of nuclei and downstream processing of cell-type-specific nuclei from micro-dissected mouse brain regions - techniques and caveats.

This paper describes a protocol for isolating cell-type-specific nuclei from micro-dissected mouse brain regions and introduces tools to assess nuclear quality and quantity.

Chronic oxytocin-driven alternative splicing of CRFR2α induces anxiety

This study shows chronic oxytocin increases soluble CRFR2, linked to anxiety, while acute oxytocin reduces anxiety via membrane-bound CRFR2.

Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons

The paper identifies genes involved in DNA damage response and translation that influence susceptibility to TOP2 poisons in gliomas and other cancers.