Author

D. T. Gewirth

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

G. Chiosis· 1 shared N. L. S. Que· 1 shared P. M. Seidler· 1 shared W. J. Aw· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

G. Chiosis

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1 paper

Recent·Most cited

BiochemistrybioRxivJul 31, 2023

Selective inhibition of hsp90 paralogs: Uncovering the role of helix 1 in Grp94-selective ligand binding

N. L. S. Que, P. M. Seidler, W. J. Aw…·D. T. Gewirth

This study investigates how Grp94-selective ligands bind to Grp94 and Hsp90 by analyzing structural changes and identifies helix 1 as a key determinant of selectivity.

DOI 10.1002/prot.26756

structural biologyexperimental assay

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