D. T. Hass

This study shows that inhibiting acetyl-CoA carboxylase with Firsocostat increases fatty acid oxidation and reduces lipid deposits in RPE cells, potentially limiting drusen accumulation in AMD.

The paper demonstrates that photoreceptors supply lactate to the RPE, supporting a metabolic exchange between these retinal cells.

This study shows that medium volume in RPE cell cultures affects O2 availability, altering metabolism and lipid droplet dynamics, and suggests optimal conditions for studying oxidative metabolism in RPE cells.

The paper identifies MCT1 as the transporter mediating succinate export from retinas but finds no MCT-mediated import into RPE.

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

The paper investigates succinate metabolism in retinal pigment epithelium and finds that succinate consumption by eyecup tissue uncouples mitochondrial ATP synthesis from respiration.

The paper shows that succinate shuttles reducing power from the hypoxic retina to the O2-rich pigment epithelium via a malate/succinate cycle.