Author

D. Tandel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Organism:non-human primate· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

K. H. Harshan· 6 shared D. Gupta· 5 shared V. Sah· 5 shared H. Parthasarathy· 4 shared A. H. Siddiqui· 2 shared D. Vedagiri· 2 shared S. Reddy· 2 shared A. P. Suresh· 1 shared

Activity by Year

2021-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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6 shared papersMicrobiology

K. H. Harshan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses

D. Tandel, V. Sah, N. K. Singh, P. S. Potharaju, D. Gupta, S. Shrivastava, D. T. Sowpati, K. H. Harshan

This study shows that the SARS-CoV-2 Delta variant suppresses innate immune responses and evades interferon activation more effectively than earlier variants.

bioRxiv · Feb 22, 2022 · PreprintImmunology

Metformin Suppresses SARS-CoV-2 in Cell Culture

H. Parthasarathy, D. Tandel, A. H. Siddiqui, K. H. Harshan

This study shows metformin inhibits SARS-CoV-2 growth in cell culture by activating AMPK, reducing viral titers by up to 99%.

bioRxiv · Nov 18, 2021Microbiology

SARS-CoV-2 Infection Causes Strong mTORC1 Inhibition and Massive Polysome Collapse

H. Parthasarathy, D. Gupta, D. Tandel, V. Sah, A. H. Siddiqui, A. P. Suresh, K. H. Harshan

This study shows SARS-CoV-2 infection inhibits mTORC1 and causes polysome collapse, but not through eIF2 phosphorylation, and allows viral mRNA translation while suppressing host mRNA translation.

bioRxiv · May 8, 2021 · PreprintMicrobiology

N440K variant of SARS-CoV-2 has Higher Infectious Fitness

D. Tandel, D. Gupta, V. Sah, K. H. Harshan

The paper investigates the N440K variant of SARS-CoV-2, finding it produces significantly higher infectious titers than two other strains in cell cultures.

bioRxiv · Apr 30, 2021 · PreprintMicrobiology

Inactivation of SARS-CoV-2 by β-propiolactone Causes Aggregation of Viral Particles and Loss of Antigenic Potential

D. Gupta, H. Parthasarathy, V. Sah, D. Tandel, D. Vedagiri, S. Reddy, K. H. Harshan

This study examines the effects of β-propiolactone on SARS-CoV-2 inactivation, finding that higher concentrations cause protein loss, antigenic degradation, and virion aggregation.

bioRxiv · Apr 22, 2021Microbiology

Development of Equine Immunoglobulin Fragment F(ab')2 with High Neutralizing Capability against SARS-CoV-2

D. Gupta, F. Ahmed, D. Tandel, H. Parthasarathy, D. Vedagiri, V. Sah, K. M. Bodduluru, S. S. Daga, R. A. Khan, C. Kondiparthi, P. Savari, S. H. Jain, J. S. Daga, S. Reddy, N. Khan, K. H. Harshan

This study develops equine-derived F(ab')2 antibodies with high neutralizing capability against SARS-CoV-2, showing effectiveness against viral variants.

bioRxiv · Mar 9, 2021 · PreprintImmunology