ImmunologyNature CommunicationsPeer-reviewed
Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility
K. Tan, J. Chen, Y. Kaku…·M. Kim
The paper shows that HIV-1 MPER-targeting antibodies generated by vaccines lack structural constraints needed to access the MPER, despite having bnAb-like paratopes.
DOI 10.1038/s41467-023-42097-6