N. Khan

Stem rot affects the structure of rhizosphere microbiome in Berseem Clover (Trifolium alexandrinum)

This study examines how stem rot disease alters the bacterial and fungal communities in the rhizosphere of berseem clover, revealing shifts in diversity and functional profiles between healthy and infected plants.

Formulation, Characterization and Pharmacokinetic Evaluation of Amorphous Solid Dispersions of Glibenclamide for Bioavailability Enhancement in Wistar Rats

This study improves the oral bioavailability of Glibenclamide by formulating amorphous solid dispersions with Poloxamer-188, showing enhanced dissolution and pharmacokinetic performance in Wistar rats.

Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation

This study shows that PfKelch13 mutants have reduced heme-binding affinity, leading to decreased artemisinin activation and contributing to artemisinin resistance.

Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment

This study identifies oleic acid as a compound that inhibits L. iners and promotes L. crispatus growth, offering a potential new treatment strategy for bacterial vaginosis.

NMR structure of the Orf63 pro-lytic protein from lambda bacteriophage

The paper determines the NMR structure of Orf63 from lambda bacteriophage and uses machine learning to design a ligand targeting its hydrophobic cleft, suggesting potential therapeutics for EHEC outbreaks.

Enhancing farmed striped catfish (Pangasianodon hypophthalmus) robustness using dietary β-glucan

This study shows that adding 1.5 g kg-1 β-glucan to the diet of striped catfish improves growth, survival, antioxidant activity, and stress resistance.

Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growth

This study identifies VEGF and IL-5 signalling pathways as aberrantly activated in t(8;21) leukemic stem cells, enabling their growth and relapse.

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1Omicron

This study compares the pathogenicity and immune evasion of an Omicron S-bearing virus with natural Omicron, showing vaccine escape via S mutations but severe disease due to factors outside S.

Mycelial nutrient transfer promotes bacterial co-metabolic organochlorine pesticide degradation in nutrient-deprived environments.

This study shows that fungal mycelia transfer nutrients to bacteria, enhancing co-metabolic degradation of organochlorine pesticides in nutrient-poor environments.

High resolution photocatalytic mapping of SARS-CoV-2 Spike protein-host cell membrane interactions

This study identifies additional host proteins involved in SARS-CoV-2 entry using a novel photocatalytic mapping platform called ViraMap.

TFAM-dependent mitochondrial integrity in regulatory T cells preserves immune landscape and restrains inflammaging

This study identifies TFAM-dependent mitochondrial integrity in Tregs as critical for preserving immune homeostasis and preventing inflammaging.

The chemokine receptor CXCR3 promotes CD8+ T cell-dependent lung pathology during influenza pathogenesis

The paper identifies CXCR3-expressing CD8+ T cells as a driver of lung pathology during influenza infection without affecting viral clearance.

Evolution of Human-specific Alleles Protecting Cognitive Function of Grandmothers

The paper investigates human-specific CD33 mutations linked to cognitive protection and Alzheimer's disease resistance, linking them to evolutionary pressures and immune evasion.

Association of EBV (Type 1 and 2) with Histopathological Outcomes in Breast Cancer in Pakistani Women

The paper investigates the association between EBV genotypes and histopathological outcomes in breast cancer patients in Pakistan, finding EBV-1 prevalence and its link to invasive ductal carcinoma.

The giant staphylococcal protein Embp facilitates colonization of surfaces through Velcro-like attachment to fibrillated fibronectin

This paper identifies Embp as a key protein in S. epidermidis that enables surface colonization by specifically binding fibrillated fibronectin through multi-valent interactions.

Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity.

This paper shows that muscle-secreted neurturin (NRTN) couples muscle oxidative metabolism with slow motor neuron identity, improving exercise performance and motor coordination.

Development of Equine Immunoglobulin Fragment F(ab')2 with High Neutralizing Capability against SARS-CoV-2

This study develops equine-derived F(ab')2 antibodies with high neutralizing capability against SARS-CoV-2, showing effectiveness against viral variants.

SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

This study identifies SARS-CoV-2 inhibition of the JAK-STAT pathway as a mechanism to suppress interferon signaling across diverse cell types.

Rearing medium dictates variability across replicates in untreated and arsenic challenged zebrafish larvae

This study shows that rearing medium affects gene expression variability and iAs toxicity in zebrafish larvae, highlighting the need for standardized experimental conditions.

The HIV-1 Vpu transmembrane domain topology and formation of a hydrophobic interface with BST-2 are critical for Vpu-mediated BST-2 downregulation

This study shows that the topology and hydrophobic interface of HIV-1 Vpu are critical for BST-2 downregulation, with shape and interface availability being more important than amino acid conservation.

Age related defects in NK cell immunity revealed by deep immune profiling of pediatric cancer patients

The paper uses high dimensional single cell analysis to reveal age-related immune changes in NK and T-cells of pediatric cancer patients and age-matched healthy children.

Impact of soil salinity on the cowpea nodule-microbiome and the isolation of halotolerant PGPR strains to promote plant growth under salinity stress

The paper examines how soil salinity affects cowpea nodule microbiomes and identifies halotolerant PGPR strains that enhance plant growth under salinity stress.

Inoculation with a microbe isolated from the Negev Desert enhances corn growth

The paper tests microbes from the Negev Desert for their ability to enhance corn growth and assesses their safety as bioinoculants.

Crystal structure of human PACRG in complex with MEIG1

The paper reports the crystal structure of human PACRG with MEIG1 and models its role in microtubule junctions, revealing interactions with tubulin and evolutionary insights.

Is useful research data usually shared? An investigation of genome-wide association study summary statistics

This paper investigates data sharing in genome-wide association studies (GWAS) and finds that only 10.6% of primary human GWAS papers report sharing summary statistics, increasing slightly from 2010 to 2017.

Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-EGFR treatment in colorectal cancer

The paper analyzes genomic and transcriptomic data from CRC patients treated with cetuximab to identify resistance mechanisms and immune landscape changes during anti-EGFR therapy.

Induction of autophagy by trehalose limits opportunistic mycobacterial infections in HIV-infected macrophages

This study shows that trehalose induces autophagy in HIV-infected macrophages, reducing mycobacterial infections by inhibiting xenophagy flux and killing intracellular pathogens.