D. Vedagiri

Regulation of eIF2α Phosphorylation by MAPKs Influences Polysome Stability and Protein Translation

This study shows that p38 MAPK and ERK1/2 regulate polysome stability and translation through integrated stress response pathways, with dual inhibition causing significant polysome collapse.

Glycolytic inhibitor 2-Deoxy-D-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions

This study shows that 2-Deoxy-D-glucose inhibits SARS-CoV-2 replication by blocking glycolysis and causing unglycosylation of the spike protein, reducing viral infectivity.

Inactivation of SARS-CoV-2 by β-propiolactone Causes Aggregation of Viral Particles and Loss of Antigenic Potential

This study examines the effects of β-propiolactone on SARS-CoV-2 inactivation, finding that higher concentrations cause protein loss, antigenic degradation, and virion aggregation.

Development of Equine Immunoglobulin Fragment F(ab')2 with High Neutralizing Capability against SARS-CoV-2

This study develops equine-derived F(ab')2 antibodies with high neutralizing capability against SARS-CoV-2, showing effectiveness against viral variants.

Retinoic Acid Inducible Gene-I like Receptors Activate Snail and Slug to Limit RNA Viral Infections

The paper shows that RLRs activate Snail and Slug to limit RNA viral infections by regulating their transcription and enhancing the antiviral response.

mTORC1 Restricts Hepatitis C Virus Replication Through ULK1-mediated Suppression of miR-122 and Facilitates Post-replication Events

This study shows mTORC1 suppresses HCV replication via ULK1-mediated reduction of miR-122 and supports post-replication events, with ULK1 depletion increasing miR-122 levels.