Author

S. D. Hursting

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. F. Coleman· 3 shared A. J. Pfeil· 2 shared E. M. Glenny· 2 shared T. L. McFarlane· 2 shared V. A. Kiesel· 2 shared A. A. Fodor· 1 shared A. G. Lewis· 1 shared A. L. Kucinskas· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

M. F. Coleman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tirzepatide restricts obesity-related tumor growth by reversing metabolic dysregulation and rescuing CD8+ T cell function

E. M. Glenny, M. F. Coleman, G. T. Clutton, B. P. Riesenberg, A. N. Ho, T. L. McFarlane, V. A. Kiesel, A. L. Kucinskas, E. G. Bailey, K. E. Sanchez, J. Zeng, Y. Wang, H. M. Malian, C. E. Gates, F. Chen, , S. D. Hursting

This study shows tirzepatide reduces obesity-related tumor growth by improving metabolism and restoring CD8+ T cell function without directly targeting cancer cells.

bioRxiv · Jan 20, 2024 · PreprintCancer Biology

Calorie Restriction Outperforms Bariatric Surgery in a Murine Model of Obesity and Triple-Negative Breast Cancer

M. F. Coleman, K. K. Camp, T. L. McFarlane, S. S. Doerstling, S. A. Khatib, E. T. Rezeli, A. G. Lewis, A. J. Pfeil, L. A. Smith, F. Fouladi, W. Gong, E. M. Glenny, J. S. Parker, G. L. Milne, I. M. Carroll, , S. D. Hursting

This study compares the effects of bariatric surgery and calorie restriction on obesity-driven triple-negative breast cancer in mice, finding calorie restriction more effective in reversing tumor growth.

bioRxiv · May 19, 2023 · PreprintCancer Biology

Hypoxia-mediated suppression of pyruvate carboxylase drives tumor microenvironment immunosuppression

M. F. Coleman, E. K. Cotul, A. J. Pfeil, E. N. Devericks, H. Chen, V. A. Kiesel, M. Safdar, D. Teegarden, S. D. Hursting, M. K. Wendt

This study shows that hypoxia suppresses pyruvate carboxylase (PC) in tumors, leading to increased lactate production and immunosuppression in the tumor microenvironment.

bioRxiv · Apr 6, 2022 · PreprintCancer Biology