MicrobiologybioRxiv
Cyclo(Pro-Tyr) elicits conserved cellular damage in fungi by targeting the ATPase Pma1 in plasma membrane domains
D. Vela-Corcia, J. Hierrezuelo, A. I. Perez-Lorente…·D. Romero
This study identifies cyclo(Pro-Tyr) as a metabolite that disrupts eukaryotic cellular membranes by targeting Pma1 ATPase in microdomains, inducing oxidative stress and membrane fluidity changes in fungi and nematodes.
DOI 10.1038/s42003-024-06947-3