D. Petras

Cyclo(Pro-Tyr) elicits conserved cellular damage in fungi by targeting the ATPase Pma1 in plasma membrane domains

This study identifies cyclo(Pro-Tyr) as a metabolite that disrupts eukaryotic cellular membranes by targeting Pma1 ATPase in microdomains, inducing oxidative stress and membrane fluidity changes in fungi and nematodes.

ASSESSING TARGET SPECIFICITY OF THE SMALL MOLECULE INHIBITOR MARIMASTAT TO SNAKE VENOM TOXINS: A NOVEL APPLICATION OF THERMAL PROTEOME PROFILING

This study uses Thermal Proteome Profiling and PISA to assess marimastat's specificity against snake venom toxins, identifying its targets and interactions with specific proteoforms.

High Resolution Biological and Physical Sampling Reveals Expression of Domoic Acid Biosynthetic Genes at Frontal Zones

This study combines high-resolution physical and multi-omic sampling to identify DA biosynthetic gene expression in frontal zones of Monterey Bay during declining upwelling.

Taxonomic and functional diversity of aquatic heterotrophs is sustained by dissolved organic matter chemodiversity

The paper investigates how dissolved organic matter (DOM) chemodiversity sustains taxonomic and functional diversity of aquatic heterotrophs across different model communities.

Spatial Venomics - Cobra Venom System Reveals Spatial Differentiation of Snake Toxins by Mass Spectrometry Imaging

This study uses MALDI-MSI to map toxin distribution in Egyptian cobra venom glands, revealing spatial heterogeneity at the proteoform level.

Discovery and characterization of the first known biological lanthanide chelator

The paper identifies and characterizes methylolanthanin, the first known lanthanide-specific metallophore, revealing its structure, biosynthesis, and role in lanthanide acquisition by bacteria.

Mutualistic interactions between B. subtilis and seeds dictate plant development

This study shows that B. subtilis interacts with seeds through its extracellular matrix components, influencing lipid metabolism and plant growth programs.

Multi-omics profiling of Earth's biomes reveals patterns of diversity and co-occurrence in microbial and metabolite composition across environments

The paper performs a multi-omics meta-analysis of microbial and metabolite data from diverse environments, revealing patterns of diversity and co-occurrence across biomes.

Chemical interplay and complementary adaptative strategies toggle bacterial antagonism and co-existence

The paper investigates how chemical interactions and mutations in two plant-beneficial bacteria influence their antagonism and coexistence.

Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut.

This study shows that the probiotic E. coli Nissle 1917 uses yersiniabactin to acquire zinc in inflamed gut conditions, enhancing its colonization.

Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras

This study shows that three spitting cobra lineages independently evolved venom with increased pain-enhancing toxins, likely in response to hominin emergence.

Fungal-bacterial interaction selects for quorum sensing mutants and a metabolic shift towards the production of natural antifungal compounds

The paper shows that B. subtilis mutants with quorum-sensing mutations produce antifungal ketones instead of surfactins when interacting with the fungus S. terrestris.

Native Electrospray-based Metabolomics Enables the Detection of Metal-binding Compounds

The paper introduces a method to detect metal-binding compounds using native electrospray ionization mass spectrometry with metal infusion and molecular networking.

Community venomics reveals intra-species variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey

This study analyzes venom composition variation in Vipera kaznakovi from Northeastern Turkey, finding age-related differences driven by small molecular weight toxins and PLA2s.

Extracellular matrix components are required to protect Bacillus subtilis colonies from T6SS-dependent Pseudomonas invasion and modulate co-colonization of plant

This study shows that the extracellular matrix protects Bacillus subtilis from Pseudomonas invasion via T6SS and influences their co-colonization on plants.