SPT6 loss Permits the Transdifferentiation of Keratinocytes into an Intestinal Fate that Recapitulates Barrett's Metaplasia
D. Vo, M. R. Fuller, C. Tindle, M. Anandachar, S. Das, D. Sahoo, P. Ghosh
The paper shows that SPT6 loss in keratinocytes leads to transdifferentiation into an intestinal fate, mimicking Barrett's metaplasia and linking acid exposure to metaplastic progression.
bioRxiv · May 6, 2021 · PreprintCell Biology