Author

C. Tindle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:cell type annotation· 6 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Research Focus:gene regulatory network inference· 3 Approach:deep learning· 2

Frequent Co-Authors

P. Ghosh· 7 shared S. Das· 6 shared D. Sahoo· 5 shared S. Taheri· 3 shared V. Castillo· 3 shared A. Fonseca· 2 shared C. R. Espinoza· 2 shared E. Vidales· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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7 shared papersCancer Biology

P. Ghosh

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Machine Learning Guided Differentiation Therapy Targets Cancer Stem Cells in Colorectal Cancers

S. Sinha, J. Alcantara, K. Perry, V. Castillo, A. Ondersma, S. Banerjee, E. McLaren, C. R. Espinoza, S. Taheri, E. Vidales, C. Tindle, A. Adel, S. Amirfakhri, J. R. Sawires, J. Yang, , P. Ghosh

This paper introduces a machine learning framework to identify and target transcriptomic vulnerabilities in colorectal cancer, demonstrating that differentiation therapy selectively eliminates cancer stem cells and reduces recurrence risk.

bioRxiv · Sep 13, 2023 · PreprintCancer Biology

A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics

C. Tindle, G. Katkar, A. Fonseca, S. Taheri, J. Lee, P. Maity, I. Sayed, S.-R. Ibeawuchi, E. Vidales, R. Pranadinata, M. Fuller, D. Stec, M. S. Anandachar, K. Perry, H. Lee, , P. Ghosh

This paper creates a biobank of patient-derived organoids to identify molecular subtypes of Crohn's disease and test subtype-specific therapies.

bioRxiv · Mar 11, 2023Immunology

AI-assisted Discovery of an Ethnicity-influenced Driver of Cell Transformation in Esophageal and Gastroesophageal Junction Adenocarcinomas

P. Ghosh, V. J. Campos, D. T. Vo, C. Guccione, V. Goheen-Holland, C. Tindle, G. S. Mazzini, Y. He, L. Alexandrov, S. M. Lippman, R. Gurski, S. Das, K. Curtius, R. Yadlapati, D. Sahoo

The paper uses AI to identify a racially influenced immune driver of esophageal and gastroesophageal junction adenocarcinomas, showing its absence in African Americans and association with neutrophil processes and genetic variants.

bioRxiv · Jan 30, 2022Cancer Biology

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

S. Sinha, V. Castillo, C. R. Espinoza, C. Tindle, A. G. Fonseca, J. M. Dan, G. D. Katkar, S. Das, D. Sahoo, P. Ghosh

This study identifies shared cellular and molecular features between severe COVID-19 and idiopathic pulmonary fibrosis, highlighting ER stress and AT2 cell dysfunction as key drivers.

bioRxiv · Nov 28, 2021Immunology

Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen

S. Saul, M. Karim, P.-T. Huang, L. Ghita, W. Chiu, S. Kumar, N. Bhalla, P. Leyssen, C. A. Cohen, K. E. Huie, C. Tindle, M. Sibai, B. A. Pinsky, S. Das, P. Ghosh, , S. Einav

This study identifies lapatinib, an ErbB inhibitor, as a broad-spectrum antiviral that suppresses SARS-CoV-2 and VEEV replication, inflammation, and lung injury through ErbB-mediated mechanisms.

bioRxiv · May 15, 2021Microbiology

SPT6 loss Permits the Transdifferentiation of Keratinocytes into an Intestinal Fate that Recapitulates Barrett's Metaplasia

D. Vo, M. R. Fuller, C. Tindle, M. Anandachar, S. Das, D. Sahoo, P. Ghosh

The paper shows that SPT6 loss in keratinocytes leads to transdifferentiation into an intestinal fate, mimicking Barrett's metaplasia and linking acid exposure to metaplastic progression.

bioRxiv · May 6, 2021 · PreprintCell Biology

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19

C. Tindle, M. Fuller, A. Fonseca, S. Taheri, S.-R. Ibeawuchi, N. Beutler, G. Katkar, A. Claire, V. Castillo, M. Hernandez, H. Russo, J. Duran, L. E. Crotty Alexander, A. Tipps, G. Lin, , S. Das

This study develops a human lung organoid model to emulate COVID-19 pathogenesis, showing proximal airway cells drive viral infection while distal cells drive excessive immune response.

bioRxiv · Oct 17, 2020Cell Biology