Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathway
S. F. Plugge, H. Ma, J. Y. van der Vaart, J. Sprangers, F. H. M. Morsink, D. Xanthakis, C. Jamieson, K. B. W. Stroot, A. R. Keijzer, T. Margaritis, T. Candelli, R. Straver, J. de Ridder, F. C. P. Holstege, W. W. J. de Leng, , M. M. Maurice
This study shows that LKB1 loss in intestinal cells leads to a pre-malignant state linked to serrated colorectal cancer, which is amplified by loss-of-heterozygosity.
bioRxiv · Jul 17, 2023 · PreprintCancer Biology