Fine-mapping HLA-II haplotypes in Alzheimer's disease and healthy longevity reveals distinct associations with microglial HLA-II load and neuropathology
Daniel Álvarez Sirvent, Maruelle C. Luimes, Niccoló Tesi…·Henne H. Holstege
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Vrije Universiteit Amsterdam
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
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3 papers
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Daniel Álvarez Sirvent, Maruelle C. Luimes, Niccoló Tesi…·Henne H. Holstege
Niccoló Tesi, Alex Salazar, Gerard A. Bouland…·Henne H. Holstege
The paper uses long-read sequencing to uncover structural complexity in Alzheimer's disease GWAS loci, showing that lead SNPs often miss key regulatory variants.
Daniel Álvarez Sirvent, Niccoló Tesi, Marc Hulsman…·Henne H. Holstege
The paper identifies six HLA alleles associated with reduced likelihood of becoming a cognitively healthy centenarian, revealing pleiotropic effects on disease susceptibility and longevity.