Alex Salazar

This study compares endogenous viral elements in Alzheimer's Disease patients and cognitively healthy centenarians using long-read sequencing, finding higher EVE burden in AD patients.

The paper uses long-read sequencing to uncover structural complexity in Alzheimer's disease GWAS loci, showing that lead SNPs often miss key regulatory variants.

The paper examines TMEM106B haplotypes and their associations with tau and TDP-43 pathologies in aging brains using integrated multi-omics data.

MotifScope identifies and visualizes tandem repeats in population context using a de novo k-mer approach, outperforming existing tools in motif discovery and representation.

The paper identifies six HLA alleles associated with reduced likelihood of becoming a cognitively healthy centenarian, revealing pleiotropic effects on disease susceptibility and longevity.

The paper introduces otter and TREAT for accurate tandem repeat genotyping across long-read sequencing platforms, showing improved accuracy and identifying pathogenic expansions and disease associations.

The paper identifies an AluYb8 retrotransposon in a TMEM106B risk haplotype associated with neurodegeneration, linking it to age-related dysregulation and population-specific disease risk.

The paper uses nanopore sequencing and a new method to show lager-brewing yeasts originated from a single hybridization event, with Group 1 and 2 strains diverging after this event.

Alpaca identifies mosaic structures in microbial genomes by analyzing kmer similarity across sequencing datasets to map evolutionary origins.

This paper presents a near-complete genome assembly of Saccharomyces cerevisiae strain CEN.PK113-7D using Nanopore sequencing, revealing new genes and a chromosomal translocation.