BiochemistrybioRxivPreprint
PI-(3,5)P2-mediated oligomerization of the endosomal sodium/proton exchanger NHE9
Surabhi Kokane, Pascal F. Meier, Ashutosh Gulati…·David Drew
This study reports cryo-EM structures of NhaA and NHE9 with lipid binding at the dimer interface, showing PI(3,5)P2 stabilizes NHE9 oligomerization and enhances activity.
DOI 10.1101/2023.09.10.557050