David Drew

The paper reports the cryo-EM structure of Pseudomonas aeruginosa LysP bound to lysine and a nanobody, revealing its transport mechanism and inhibition by L-4-thialysine.

The paper investigates how cardiolipin interacts with membrane proteins to stabilize them, using a model protein and simulations to identify key factors.

This study uses a CRISPR homing screen to identify essential genes for malaria transmission in mosquito stages, finding a chloroquine resistance transporter-like protein critical for oocyst development.

This study reports the cryo-EM structure of a TRAP transporter from Haemophilus influenzae, revealing its dimeric architecture, Na+ sites, and substrate binding site, supported by mutagenic and functional data.

This study reports cryo-EM structures of NhaA and NHE9 with lipid binding at the dimer interface, showing PI(3,5)P2 stabilizes NHE9 oligomerization and enhances activity.

The paper reports the cryo-EM structure of a TRAP transporter and elucidates its mechanism of sodium-driven substrate uptake.