Tanadet Pipatpolkai

This paper identifies a novel TRPA1 variant causing painful sensory neuropathy and shows it functions through a PIP2-dependent mechanism.

This study uses PIP2-assisted adaptive sampling to model conductive conformations of TMEM16A, revealing key structural features and validating pore blocker binding sites.

This study investigates how synthetic cannabinoid receptor agonists affect cardiac ion channels, finding that most inhibit hERG and some also inhibit KV7.1/KCNE1.

This study investigates how KCNE1 and KCNE3 modulate KCNQ1 gating through PIP2-dependent mechanisms, revealing distinct roles in voltage sensitivity and GPCR regulation across cell types.

This study identifies a novel binding pocket in the SCAP-INSIG complex involved in cholesterol recognition using molecular dynamics simulations and AlphaFold3.

This study introduces PIC-NIC, a method to systematically perturb DNA binding sites without altering base sequences, revealing how DNA backbone structure influences transcription factor binding.

This study shows that intracellular zinc dynamically regulates the Slo3 potassium channel in mouse spermatozoa during capacitation, inhibiting currents and mediating alkalinization-induced hyperpolarization.

This study uses molecular dynamics to show how fluoxetine and escitalopram inhibit TREK-2 channels through different mechanisms involving the selectivity filter and lipid interactions.

This study reports cryo-EM structures of NhaA and NHE9 with lipid binding at the dimer interface, showing PI(3,5)P2 stabilizes NHE9 oligomerization and enhances activity.