NeurosciencePLoS ONEPeer-reviewed
Progranulin deficiency leads to reduced glucocerebrosidase activity
Xiaolai Zhou, Daniel H. Paushter, Mitchell D. Pagan…·Fenghua Hu
This study shows that progranulin deficiency reduces glucocerebrosidase activity, linking it to lysosomal dysfunction in neurodegenerative diseases.
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