NeurosciencebioRxiv
Microglial homeostasis requires balanced CSF-1/CSF-2 receptor signaling
Violeta Chiţu, Fabrizio Biundo, Gabriel G. L. Shlager…·E. Richard Stanley
This study shows that reducing CSF-2 in Csf1r+/- mice rescues behavioral and histopathological deficits in ALSP by preventing microgliosis and transcriptomic changes, suggesting CSF-2 as a therapeutic target.