E. Richard Stanley

This study identifies CSF-1 signaling as a key mechanism in TMEM doorway function, showing its role in promoting vascular openings and tumor cell intravasation in breast cancer.

This study develops a mouse model of Polr3-related disease and identifies tRNA pool changes as a causal factor in neurodegeneration.

This study shows that reducing Csf3 in Csf1r+/- mice improves anxiety, motor coordination, and social interaction but not cognitive deficits, and reduces microglial activation in the cerebellum.

This study shows that reducing CSF-2 in Csf1r+/- mice rescues behavioral and histopathological deficits in ALSP by preventing microgliosis and transcriptomic changes, suggesting CSF-2 as a therapeutic target.

This study shows that CSF-1 signaling is essential for cerebellar microglia identity and function, and its disruption causes motor and social behavior defects.