Author

Darcy Reil

University of Massachusetts Chan Medical School

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Molecular Biology· 1

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Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

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Alisha M. GruntmaniD· 1 shared April Destefano· 1 shared Dan WangiD· 1 shared Fang ZhangiD· 1 shared Guangchao XuiD· 1 shared Guangping GaoiD· 1 shared Jialing Liang· 1 shared Li Luo· 1 shared

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Alisha M. GruntmanORCID

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1 paper

Recent·Most cited

Molecular BiologyPLoS PathogensPeer-reviewedSep 17, 2025

A single amino acid variant in the variable region I of AAV capsid confers liver detargeting

Ruxiao Xing, Mengyao Xu, Darcy Reil…·Dan Wang

The paper identifies an amino acid variant in AAV capsid VR-1 that reduces liver targeting, suggesting its potential for minimizing liver toxicity in gene therapy.

8 citationstop 4%

mouseDNA methylation

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