Author

David Brough

Primary ORCID profile (0000-0002-2250-2381 · 11 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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David BroughiD11 papers · Manchester Academic Health Science Centre

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Fatima Martin-Sanchez· 1 shared Gloria Lopez-CastejoniD· 1 shared Siyi Bai· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperImmunology

Fatima Martin-Sanchez

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintNov 22, 2023

Pyroptosis leads to loss of centrosomal integrity in macrophages

Siyi Bai, Fatima Martin-Sanchez, David Brough, Gloria Lopez-Castejon

This study shows that NLRP3 inflammasome activation in macrophages leads to loss of centrosomal scaffold protein PCNT, affecting centrosome structure and potentially contributing to inflammatory disease pathogenesis.

DOI 10.1101/2023.11.22.568260

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