Cancer BiologybioRxivPreprint
eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers
Joseph A. Waldron, Georgios Kanellos, Rachael C.L. Smith…·Owen James Sansom
This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.
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