Rachael C.L. Smith

This paper shows that Pabpc4 is not essential for development but is important for post-natal growth, survival, and hematopoiesis in mice, with effects on red blood cell morphology.

This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.