NeuroscienceNeurobiology of DiseasePeer-reviewed
Parkinsons Disease Pathology is Directly Correlated to SIRT3 in Human Subjects and Animal Models: Implications for AAV.SIRT3-myc as a Disease-Modifying Therapy.
Dennison Trinh, Ahmad R. Israwi, Harsimar Brar…·Joanne E. Nash
This paper shows SIRT3 levels decrease with age and in Parkinson's disease, and over-expression of SIRT3 reduces α-synuclein aggregation, supporting AAV.SIRT3-myc as a potential therapy.