Evolutionary BiologybioRxivPreprint
Higher-order epistasis drives evolutionary unpredictability toward novel antibiotic resistance
Ilona Kamila Gaszek, Muhammed Sadik Yildiz, Devin Meng…·Erdal Toprak
This study constructs a comprehensive mutant library of TEM-1 beta-lactamase and shows that higher-order epistasis drives unpredictable evolution of antibiotic resistance to novel substrates.
4 citations