Ilona Kamila Gaszek

This study maps how β-lactamase mutations confer resistance to different antibiotics, identifying generalist and specialist mutations with distinct mechanisms and positions.

This study constructs a comprehensive mutant library of TEM-1 beta-lactamase and shows that higher-order epistasis drives unpredictable evolution of antibiotic resistance to novel substrates.

This study investigates TolC protein dynamics in Gram-negative bacteria, identifying structural shifts that facilitate β-lactam efflux and resistance, with implications for antibiotic design.

The study shows that the TolC protein in E. coli is highly evolvable, making it a target for resistance against bacteriophages and bacterial toxins.