Cancer BiologybioRxiv
Targeting Heterochromatin Eliminates Malignant Stem Cells in Chronic Myelomonocytic Leukemia Through Reactivation of Retroelements and Innate Immune pathways
Donia Hidaoui, Audrey Porquet, Rabie Chelbi…·Françoise Porteu
This study shows that combining DNA hypomethylating agents with H3K9me2 inhibitors reactivates immune pathways and eliminates malignant stem cells in CMML by targeting heterochromatin disorganization.
DOI 10.1038/s42003-024-07214-1