Eirini Trompouki

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

This study identifies p16High immune cells as critical for disease tolerance, showing they enhance survival in various conditions and extend healthspan by maintaining low adenosine levels.

This study shows that cGAS-STING contributes to premature aging in telomerase-deficient zebrafish by promoting senescence and inflammation, and its absence rescues aging-related phenotypes.

This study shows that combining DNA hypomethylating agents with H3K9me2 inhibitors reactivates immune pathways and eliminates malignant stem cells in CMML by targeting heterochromatin disorganization.

This study shows PD-L1 blockade in tumor-bearing mice targets bone marrow HSPCs, reprograms their transcriptome toward inflammation, and reduces myeloid-derived suppressor cells.

This study investigates how DOT1L methyltransferase activity affects chromatin states and gene expression during neuronal differentiation of mouse embryonic stem cells.