ImmunologybioRxivPreprint
Glutarate regulates T cell function and metabolism
E. A. Minogue, P. P. Cunha, A. Quaranta…·R. S. Johnson
This study shows that glutarate regulates T cell function and metabolism by inhibiting KGDDs and modifying the pyruvate dehydrogenase E2 subunit, enhancing CD8+ T cell cytotoxicity and reducing tumor growth.
DOI 10.1101/2022.10.20.513065