Author

C. Wheelock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:metabolomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

K.-i. Kamei· 2 shared R. ABDALKADER· 2 shared R. Chaleckis· 2 shared A. Quaranta· 1 shared B. Wadsworth· 1 shared D. Bargiela· 1 shared E. A. Minogue· 1 shared G. Grice· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

K.-i. Kamei

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Author profile →

3 papers

Recent·Most cited

Glutarate regulates T cell function and metabolism

E. A. Minogue, P. P. Cunha, A. Quaranta, J. Zurita, S. K. Sah-Teli, B. Wadsworth, R. Hughes, G. Grice, P. Velica, D. Bargiela, L. Barbieri, C. Wheelock, J. A. Nathan, P. Karppinen, I. P. Foskolou, R. S. Johnson

This study shows that glutarate regulates T cell function and metabolism by inhibiting KGDDs and modifying the pyruvate dehydrogenase E2 subunit, enhancing CD8+ T cell cytotoxicity and reducing tumor growth.

bioRxiv · Oct 20, 2022 · PreprintImmunology

Spatiotemporal Determination of Metabolite Activities in Multiple Corneal Epithelium Barriers on a Chip

R. ABDALKADER, R. Chaleckis, C. Wheelock, K.-i. Kamei

This study introduces Cornea-Chip to analyze spatiotemporal metabolite dynamics in corneal epithelium barriers using metabolomics and mRNA analysis.

bioRxiv · Jan 8, 2021Bioengineering

Untargeted LC-MS metabolomics for the analysis of micro-scaled extracellular metabolites from hepatocytes

R. Abdalkader, R. Chaleckis, I. Meister, P. Zhang, C. Wheelock, K.-i. Kamei

The paper develops an LC-MS-based untargeted metabolomics protocol to analyze micro-scale extracellular metabolites from hepatocytes and identifies metabolite shifts over time.

bioRxiv · Sep 24, 2020Bioengineering