CLIC4 is regulated by RhoA-mDia2 signaling through Profilin-1 binding to modulate filopodia length
E. Argenzio, K. M. Kedziora, L. Nahidiazar, T. Isogai, A. Perrakis, K. Jalink, W. H. Moolenaar, M. Innocenti
This study identifies RhoA-mDia2 signaling and Profilin-1 binding as regulators of CLIC4 translocation, which modulates filopodia length through actin dynamics.
bioRxiv · Feb 2, 2018Cell Biology