Author

K. Jalink

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 7

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Research Focus:cell signaling & trafficking· 5 Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:fluorescence / live-cell microscopy· 2 Approach:microscopy & imaging analysis· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. van den Broek· 3 shared J. Klarenbeek· 3 shared A. Perrakis· 2 shared K. M. Kedziora· 2 shared L. Nahidiazar· 2 shared S. Mukherjee· 2 shared W. H. Moolenaar· 2 shared A. B. Houtsmuller· 1 shared

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2016-2024 · peak 2/yr

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10 top collaborators · 13 mutual co-author links

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3 shared papersCell Biology

B. van den Broek

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7 papers

Recent·Most cited

Radical differences between two FLIM microscopes affect interpretation of cell signaling dynamics

S. Mukherjee, J. Klarenbeek, F. El Oualid, B. van den Broek, K. Jalink

This study compares two FLIM microscopes and finds that differences in cAMP kinetics are due to phototoxicity from FluoroBrite medium, not the imaging technique itself.

iScience · Jul 1, 2024Peer-reviewedCell Biology

DNA end-resection in highly accessible chromatin produces a toxic break

J. van den Berg, S. E. P. Joosten, Y. Kim, A. G. Manjon, L. Krenning, L. Koob, F. M. Feringa, R. Klompmaker, B. van den Broek, K. Jalink, W. Zwart, R. H. Medema

The authors withdrew their manuscript due to inconsistencies in data and questionable experimental results regarding DNA end-resection and chromatin accessibility.

bioRxiv · Aug 30, 2021 · PreprintCell Biology

Dynamic FRET-FLIM based screens of signal transduction pathways: a feasibility study

R. Harkes, O. Kukk, S. Mukherjee, J. Klarenbeek, B. van den Broek, K. Jalink

The paper demonstrates a FRET-FLIM platform for analyzing cAMP dynamics in HeLa cells, finding that PDE3A and PDE10A significantly slow cAMP decay.

bioRxiv · May 23, 2021Cell Biology

Modular actin nano-architecture enables podosome protrusion and mechanosensing

K. van den Dries, L. Nahidiazar, J. A. Slotman, M. B. M. Meddens, E. Pandzic, B. Joosten, M. Ansems, J. Schouwstra, A. Meijer, R. Steen, M. Wijers, J. Fransen, A. B. Houtsmuller, P. W. Wiseman, K. Jalink, A. Cambi

This study identifies the modular actin nano-architecture of podosomes, showing how different actin modules enable protrusion and mechanosensing on varying substrate stiffness.

bioRxiv · Mar 20, 2019Cell Biology

TRPM7 residue S1269 mediates cAMP dependence of Ca2+ influx

J. Broertjes, J. Klarenbeek, Y. Habani, M. Langeslag, K. Jalink

The paper identifies TRPM7 residue S1269 as mediating cAMP-dependent inhibition of Ca2+ influx in neuroblastoma cells.

bioRxiv · Feb 26, 2018Cell Biology

CLIC4 is regulated by RhoA-mDia2 signaling through Profilin-1 binding to modulate filopodia length

E. Argenzio, K. M. Kedziora, L. Nahidiazar, T. Isogai, A. Perrakis, K. Jalink, W. H. Moolenaar, M. Innocenti

This study identifies RhoA-mDia2 signaling and Profilin-1 binding as regulators of CLIC4 translocation, which modulates filopodia length through actin dynamics.

bioRxiv · Feb 2, 2018Cell Biology

Negative regulation of uPAR activity by a GPI-specific phospholipase C

M. van Veen, E. Matas-Rico, K. van de Wetering, D. Leyton-Puig, K. M. Kedziora, N. Sidenius, K. Jalink, A. Perrakis, W. H. Moolenaar

This study identifies GDE3 as a GPI-specific phospholipase C that cleaves uPAR, reducing its proteolytic and non-proteolytic activities and altering cell behavior in breast cancer.

bioRxiv · Dec 20, 2016Cell Biology